Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Subramanian, S.
- 4(R)-5, 10, Seco 19-Norpregna 4,5 Diene 3, 10, 20 Trione (Seco), an Inhibitor of Epididymal 5α-Reductase Arrests Sperm Forward Motility in Wistar Rats
Abstract Views :311 |
PDF Views:0
Authors
Affiliations
1 Department of Endocrinology, Dr. ALM. PG. Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, IN
1 Department of Endocrinology, Dr. ALM. PG. Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai - 600 113, IN
Source
Journal of Endocrinology and Reproduction, Vol 3, No 1&2 (1999), Pagination: 95-111Abstract
The effect of 4(R) - 5, 10, Seco 19 - norpregna 4,5 diene 3,10, 20 trione (SECO), a potent inhibitor of 5α-reductase, an intracellular enzyme that converts testosterone to dihydrotestosterone (DHT), on epididymal sperm count and motility was studied in Wistar rats. Administration of (i.m.) 250, 500, 750,1000 μg SECO/Kg b.wt/day to mature rats for 45 days impaired sperm forward motility in a dose dependent manner. Epididymal weight and sperm number decreased in rats treated with 750 and 1000 μg SECO, whereas weight of other accessory organs decreased in rats treated with 1000 μg SECO only. The epididymal histology showed degraded sperm and increased number of clear cells indicating high endocytotic activity, to clear dead sperm, whereas no obvious change was observed in the testicular histology. SECO treatment increased testosterone concentration whereas, it decreased estradiol concentration in circulation and in the epididymal tissue. SECO treatment specifically decreased 5α-reductase in epididymis without affecting the same in the liver, indicating its targeted effect on the epididymis. Thus, the preliminary in vivo study points out that SECO impairs the acquisition of sperm forward motility.Keywords
Epididymis, 5α-Reductase Inhibitor, SECO, Sperm Fordward Motility.- Gestational Exposure to Chromium Alters the Histoarchitecture of Adult Rat Testis: a Light Microscopic Study
Abstract Views :182 |
PDF Views:0
Authors
P. Sekhar
1,
S. Subramanian
2,
N. S. Venkatesh
2,
A. M. J. Sashi
2,
N. Kalpana
2,
J. Anbalagan
2,
G. Vengatesh
2,
P. Govindarajulu
2,
M. A. Akbarsha
3,
M. M. Aruldhas
2
Affiliations
1 Post Graduate Department of Zoology, Voorhees College, Vellore-632001, IN
2 Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, IN
3 Department of Animal Science, Bharathidasan University, Tiruchirappalli-620024, IN
1 Post Graduate Department of Zoology, Voorhees College, Vellore-632001, IN
2 Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, IN
3 Department of Animal Science, Bharathidasan University, Tiruchirappalli-620024, IN
Source
Journal of Endocrinology and Reproduction, Vol 7, No 1&2 (2003), Pagination: 86-87Abstract
Heavy metals and chemicals are known to cause male infertility. Chromium, an occupational heavy metal pollutant is a wellknown carcinogen with toxic effect on skin, lung and kidney. A few early reports point out the reproductive toxicity of chromium in experimental animals. An extensive study conducted in our laboratory in adult rats and monkeys established that altered prooxidant - antioxidant balance leading to free radical toxicity in the testis as the mechanism underlying the reproductive toxicity of chromium.- Gestational Exposure to Chromium Interferes with Post-Natal Development and Growth of the Thyroid Gland through Altered TSH
Abstract Views :161 |
PDF Views:0
Authors
Affiliations
1 Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, IN
1 Department of Endocrinology, University of Madras, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani Campus, Chennai-600113, IN